The Missouri Highway Patrol says the two drivers suffered "non-life threatening injuries".
MoDOT's website says the eastbound lane is now open, but drivers should still expect delays.
A crash is closing part of I-44 near mile marker 29 (close to the Sarcoxie exit). Authorities say the crash was in the eastbound lanes. Traffic was stopped in both directions, but is now open in the westbound lanes, according to MoDOT's website. MoDOT estimates the road will remain closed for five hours.
No word on any injuries at this time.
We have a crew on the way and will have the latest on KOAM News at 6.
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